Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats

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Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats

The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC). In the central nervous system, the locus coeruleus (LC) is known to be a region that expresses the heme oxygenase enzyme (HO), which catalyzes the metabolism of ...

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Effect of heme oxygenase–endogenous carbon monoxide on mortality during septic shock in rats

AIM To investigate the effect of HO–CO on mortality during septic shock in rats. METHOD Eighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ. RESULTS Death was significantly lower in group SS than in group LZ (P < 0.05). The MAP was significantly higher in the group LZ than in the group SS (P < 0.05). ALT, AST, Cr and BUN, MDA, and the lung EB contents...

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Heme oxygenase/carbon monoxide in the female reproductive system: an overlooked signalling pathway.

For a long time, carbon monoxide (CO) was known for its toxic effect on organisms. But there are still many things left to discover on that molecule. CO is formed directly in the body by the enzymatic activity of heme oxygenase (HO). CO plays an important role in many physiological processes, such as cell protections (against various stress factors), and the regulation of metabolic processes. R...

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Cytoprotection of heme oxygenase-1/carbon monoxide in lung injury.

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Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat.

The enzyme heme oxygenase (HO), which exists in inducible (HO-1) and constitutive (HO-2) isoforms, degrades heme to biliverdin and CO. CO depresses cardiac contraction via cGMP. We aimed to clarify a possible role for the HO-CO pathway in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Four weeks after bile duct ligation or sham operation, rat ventricles were examined fo...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2016

ISSN: 1414-431X,0100-879X

DOI: 10.1590/1414-431x20165135